Stroke Recovery System

Designed to enable recovery as part of post-stroke rehabilitation

Cortigent is developing the Stroke Recovery System to improve hand and arm recovery by pairing targeted motor cortex stimulation with structured rehabilitation.

The recovery challenge

Many stroke survivors live with persistent weakness or paralysis of one side of the body

Persistent weakness or paralysis can limit independence long after a stroke. Cortigent’s initial focus is improving recovery of hand and arm function.

Hands and armsThe initial development focus is recovery of upper-limb function.

Rehabilitation remains centralThe system is designed to work alongside, not replace, rehabilitation therapy.

Neuroplasticity rationaleThe planned program is intended to investigate cortical stimulation delivered alongside structured rehabilitation.

Illustration of the nervous system and brain

Program concept

Precision stimulation integrated with rehabilitation

1

Map the motor cortex

Identify the cortical region associated with affected hand and arm movement.

2

Place the surface array

Position the multi-electrode array directly on selected areas of the motor cortex.

3

Deliver stimulation

Apply controlled stimulation patterns during a defined rehabilitation protocol.

4

Measure recovery

Use approved clinical scales and functional outcomes to evaluate safety and performance.

Precision control at the motor cortex

The precision neurostimulation technology platform shared with Orion uses an array of sixty independently controlled electrodes to deliver programmed electrical micro-pulses to selected motor cortex regions.

Explore the platform

Illustration of a Cortigent cortical-surface implant

Clinical foundation

Prior clinical research informs further development of cortical stimulation

Earlier Northstar Neuroscience studies evaluated cortical stimulation used with rehabilitation following stroke. Results from their phase 3 study provide learnings that our technology platform is uniquely tailored to address.

Third-party evidenceNorthstar
NeurosciencePrior studies provide clinical evidence for the approach.
Cortigent approach60-electrode
cortical arraySurface placement with software-controlled stimulation patterns.
Planned evaluationFuture
clinical studySubject to financing, FDA authorization and approved protocol.

The Northstar Neuroscience studies used a different device than Cortigent’s Stroke Recovery System.

A planned path towards development and clinical evaluation

Device development

Build and verify program-specific devices; research and development work is underway.

Regulatory submission

Seek FDA authorization for the planned clinical study.

Clinical initiation

Target the first patient in late 2027, subject to financing, FDA authorization and site readiness.

Study results

Plan interim safety reporting and top-line results approximately two years after Early Feasibility Study initiation.